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lcmodel analysis program  (Provencher Inc)

 
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    Provencher Inc lcmodel analysis program
    Lcmodel Analysis Program, supplied by Provencher Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/lcmodel+analysis+program/software+tool+lcmodel/pm34419762-68-8-13
    Average 90 stars, based on 1 article reviews
    lcmodel analysis program - by Bioz Stars, 2026-11
    90/100 stars

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    Article Title: Glutamate levels in the medial prefrontal cortex of healthy pregnant women compared to non-pregnant controls.
    Article Snippet: Very little is known about maternal cerebral changes during pregnancy.. Since there is an increased risk for major depression during pregnancy and postpartum, it is important to understand the structural and neurochemical changes that occur in the brain during pregnancy.. Using proton magnetic resonance spectroscopy (1H-MRS) (3 T field strength), glutamate (Glu) levels were measured in the medial prefrontal cortex (MPFC) of 21 healthy gravid subjects 2–3 weeks before their due date (6.74 ± 1.39), and in 14 non-pregnant healthy controls during their follicular phase (8.53 ± 1.55).

    Article Title: Lower Glutamate Levels in Rostral Anterior Cingulate of Chronic Cocaine Users - A 1 H-MRS Study Using TE-Averaged PRESS at 3T with an Optimized Quantification Strategy
    Article Snippet: Improved spectral quantification strategy for Glu The MRS data were quantified using the LCModel analysis program ( Provencher, 1993 ) with a basis set consisting of the model spectra of NAA, tCr, tCho, Glu, Gln, myo -inositol (Ins) and a separate set of common macromolecules (MM) and lipid.

    Article Title: Lower Glutamate Levels in Rostral Anterior Cingulate of Chronic Cocaine Users - A 1 H-MRS Study Using TE-Averaged PRESS at 3T with an Optimized Quantification Strategy
    Article Snippet: The MRS data were quantified using the LCModel analysis program ( Provencher, 1993 ) with a basis set consisting of the model spectra of NAA, tCr, tCho, Glu, Gln, myo -inositol (Ins) and a separate set of common macromolecules (MM) and lipid.

    Article Title: Elevated 3T proton MRS glutamate levels associated with poor Continuous Performance Test (CPT-0X) scores and genetic risk for schizophrenia.
    Article Snippet: Glutamate was quantified by proton magnetic resonance spectroscopy (H-MRS) in the medial frontal lobes of 15 adult siblings of individuals with schizophrenia (HR) and 14 healthy volunteers (HV), all of whom also completed a Continuous Performance Test (CPT).. Subjects were free of psychopathology but the HR group showed greater variability in glutamate levels.. After median stratification, the high glutamate group contained a larger proportion of HR than HV subjects and scored lower on the CPT.



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    lcmodel (version 6.0-1) analysis program  (Provencher Inc)
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    Provencher Inc lcmodel (version 6.0-1) analysis program
    Simulation used to optimize the stimulated echo acquisition mode (STEAM) settings. (a) Simulated metabolite magnetic resonance (MR) spectra for STEAM {TE,TM}={240, 27 ms} centered on the spectral region surrounding the Glu multiplet at ∼2.35 p.p.m. Metabolites at equimolar concentrations include: glutamate (Glu), glutamine (Gln), glutathione (GSH), homocarnosine (HC), γ-aminobutyric acid (GABA), and N-acetylaspartate (NAA). (b) Scaled metabolite spectra based on typical literature concentrations (relative to Glu at 100%), NAA (120%), GABA (15%), HC (3%), GSH (20%), and Gln (40%). No significant overlap with the target Glu signal arises from GSH or HC. Since the NAA-asparate signal amplitude is well characterized by its singlet, its overlap as a contaminating signal can be readily accounted for during <t>LCModel</t> analysis. Within the Glu target band, only Gln (Gln peak/Glu peak ∼8%) and GABA (∼7%) contamination will have a minor impact on quantification under these optimized stimulated echo acquisition mode (STEAM) acquisition timings.
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    Simulation used to optimize the stimulated echo acquisition mode (STEAM) settings. (a) Simulated metabolite magnetic resonance (MR) spectra for STEAM {TE,TM}={240, 27 ms} centered on the spectral region surrounding the Glu multiplet at ∼2.35 p.p.m. Metabolites at equimolar concentrations include: glutamate (Glu), glutamine (Gln), glutathione (GSH), homocarnosine (HC), γ-aminobutyric acid (GABA), and N-acetylaspartate (NAA). (b) Scaled metabolite spectra based on typical literature concentrations (relative to Glu at 100%), NAA (120%), GABA (15%), HC (3%), GSH (20%), and Gln (40%). No significant overlap with the target Glu signal arises from GSH or HC. Since the NAA-asparate signal amplitude is well characterized by its singlet, its overlap as a contaminating signal can be readily accounted for during LCModel analysis. Within the Glu target band, only Gln (Gln peak/Glu peak ∼8%) and GABA (∼7%) contamination will have a minor impact on quantification under these optimized stimulated echo acquisition mode (STEAM) acquisition timings.

    Journal: Neuropsychopharmacology

    Article Title: Increased Glutamate Levels in the Medial Prefrontal Cortex in Patients with Postpartum Depression

    doi: 10.1038/npp.2012.101

    Figure Lengend Snippet: Simulation used to optimize the stimulated echo acquisition mode (STEAM) settings. (a) Simulated metabolite magnetic resonance (MR) spectra for STEAM {TE,TM}={240, 27 ms} centered on the spectral region surrounding the Glu multiplet at ∼2.35 p.p.m. Metabolites at equimolar concentrations include: glutamate (Glu), glutamine (Gln), glutathione (GSH), homocarnosine (HC), γ-aminobutyric acid (GABA), and N-acetylaspartate (NAA). (b) Scaled metabolite spectra based on typical literature concentrations (relative to Glu at 100%), NAA (120%), GABA (15%), HC (3%), GSH (20%), and Gln (40%). No significant overlap with the target Glu signal arises from GSH or HC. Since the NAA-asparate signal amplitude is well characterized by its singlet, its overlap as a contaminating signal can be readily accounted for during LCModel analysis. Within the Glu target band, only Gln (Gln peak/Glu peak ∼8%) and GABA (∼7%) contamination will have a minor impact on quantification under these optimized stimulated echo acquisition mode (STEAM) acquisition timings.

    Article Snippet: The in vivo data were analyzed using the LCModel (version 6.0-1) analysis program ( Provencher, 1993 ).

    Techniques: Serial Time-encoded Amplified Microscopy

    Sample stimulated echo acquisition mode (STEAM) localized magnetic resonance spectroscopy (MRS) data acquired from the medial prefrontal cortex and with sequence timings optimized for recovering signal from glutamate (STEAM TE, TM=240, 27 ms). The spectra illustrate the unfiltered data superimposed with the LCModel fit in red. Glu, glutamate; NAA+NAAG, N-acetylaspartate plus N-acetylaspartylglutamate; t-Cr, creatine plus phosphocreatine; t-Cho, glycerophosphorylcholine plus phosphorylcholine; p.p.m., parts per million.

    Journal: Neuropsychopharmacology

    Article Title: Increased Glutamate Levels in the Medial Prefrontal Cortex in Patients with Postpartum Depression

    doi: 10.1038/npp.2012.101

    Figure Lengend Snippet: Sample stimulated echo acquisition mode (STEAM) localized magnetic resonance spectroscopy (MRS) data acquired from the medial prefrontal cortex and with sequence timings optimized for recovering signal from glutamate (STEAM TE, TM=240, 27 ms). The spectra illustrate the unfiltered data superimposed with the LCModel fit in red. Glu, glutamate; NAA+NAAG, N-acetylaspartate plus N-acetylaspartylglutamate; t-Cr, creatine plus phosphocreatine; t-Cho, glycerophosphorylcholine plus phosphorylcholine; p.p.m., parts per million.

    Article Snippet: The in vivo data were analyzed using the LCModel (version 6.0-1) analysis program ( Provencher, 1993 ).

    Techniques: Serial Time-encoded Amplified Microscopy, Spectroscopy, Sequencing